Last Updated on May 1, 2024 by Katrina

Photo credit: Grand Bohemian Lodge Greenville

Located midway between Atlanta and Asheville, the South Carolina city of Greenville offers a getaway rich with both cultural charm and natural beauty. Greenville’s walkable downtown features plenty of dining, shopping, live entertainment, and even its own waterfall, next to the photo-op-ready Liberty Bridge. Stay in or near downtown to explore the city center, or use it as a launching pad for experiencing more of the 50 waterfalls in the area. Here are best hotels in Greenville.

The Westin Poinsett, Greenville (120 S Main St.; 864-421-9700) Downtown

Travel+Leisure calls this Westin, housed in a 1925 Beaux Arts building, a “landmark property” that offers “upscale accommodations and a warm, welcoming staff.” Online users like such amenities as the Heavenly Beds, the free airport shuttle, and the relatively low charge for self-parking. One Tripadvisor user likes the “old school charm and walking distance to all Greenville attractions, and we really enjoyed the piano player who played in the lobby.” Another commends “the comfortable room with a great mattress, and the wonderful coffee and cinnamon rolls at the coffee shop downstairs.”  >> Book this hotel for less

Grand Bohemian Lodge Greenville, Autograph Collection (44 E Camperdown Way; 864520-5300) Downtown

This 187-room hotel overlooking Reedy River Falls and Liberty Bridge “marries high-end service and accommodations with a rustic sensibility,” according to Condé Nast Traveler. Even though you are walking distance from most downtown sights, the interior exudes wilderness lodge ambience, thanks in part to its giant stone fireplace. A Google reviewer likes the “comfortable, perfect layout” of their room and calls the hotel “absolutely beautiful inside and out. The architecture blends with the stunning river and waterfall views. Plenty of outdoor seating areas to relax and enjoy the views.”

Hyatt Regency Greenville (220 N Main St.; 864-235-1234) Downtown

You have a front row seat for downtown festivities at this 328-room Hyatt Regency, including the live music and food trucks on Thursday and Friday night. One Tripadvisor reviewer calls it “a beautiful hotel” while another also loved the nearby “Kilwins, just outside, for evening ice cream. Self-parking is in a public parking deck, but it’s attached to the hotel and $7/day.” One Google reviewer liked the very-Greenville touch of an indoor waterfall. “Very nice lobby, plenty of sitting for relaxing with the nice sound from the waterfall. Fun being on Main Street.”  >> Book this hotel for less

Hotel Hartness (120 Halston Ave.; 864-686-8900) East Side

Staying at this 73-room boutique hotel will make you feel like a Greenville insider. The hotel was created out of the Hartness estate, the former home of a prominent Greenville family. A Google reviewer likes that the hotel is “located within a residential neighborhood rather than off an interstate or center of downtown. The property gives the feeling of a country villa…The former TV room is a very intimate lounge and bar.” The hotel has a pool plus hiking and biking trails, too. “The grounds are beautiful,” adds a Tripadvisor user. “f you are a runner, like to walk, or ride a bike, there is plenty of territory to cover.”

Cambria Hotel Greenville (135 Carolina Point Pkwy.; 864-990-0297) The Point

“Modern, clean and trendy” is how one Google reviewer describes this 126-room boutique hotel 20 minutes from downtown and across from the popular shopping center The Point. The food and family entertainment options around the hotel were endless. All of our travel from this location was 15 minutes or less.” The property also has a pool and outdoor fire pits. One Yelper says it exceeded expectations at this price point. “The room was massive, with high ceilings and great amenities—great soaps, new tv, wall chargers and lights everywhere.”  >> Book this hotel for less