Last Updated on May 20, 2024 by Laura

Photo credit: Cheeca Lodge

Leave your passport at home for a tropical getaway to the Florida Keys. This 125-mile archipelago stretches from just south of Miami to Key West. Its islands offer all the beauty, history, wildlife and beaches of the Caribbean. But, better yet, you can skip the hassle of an international hop. In addition, there is no shortage of plush accommodations across the Keys, giving travelers a truly blissful vacation. Here are the best luxury hotels in the Florida Keys.

Little Palm Island Resort & Spa (28500 Overseas Hwy., 305-684-8341) Little Torch Key

America’s only private island resort, Little Palm Island is a paradise with thatched roof bungalows, a spa and world-class cuisine. You get there by boat or plane, then can indulge in isolation and serenity. A Tripadvisor user raves: “The resort was magnificent and everything about our stay was a dream! From the location, to the amenities and service…we were so impressed with our stay that we’re thinking of booking another trip very soon.”     >> Book this hotel for less

Cheeca Lodge & Spa (81801 Overseas Hwy., 305-664-4651) Islamorada

This lively resort in Islamorada has activities for every age. Besides a fishing pier, you’ll find a 9-hole golf course, six tennis courts, a fitness center, multiple pools, and watersports. In addition, it’s just five miles from Windley Fossil Reef Geological State Park, where you can hike and see fossilized coral. “No two ways around it, it’s a tropical paradise,” raves a Yelp reviewer. “Pools, dense impossibly manicured foliage, sea, sky, it’s all there. Guests really don’t have to leave once on the property, though of course I would recommend getting out and seeing more of the surrounding area.”     >> Book this hotel for less

The Moorings Village (123 Beach Rd., 305-664-4708) Islamorada

In the 1960s, a former coconut plantation transformed into The Moorings Village. Its luxurious cottages afford its guests plenty of space and privacy. Plus, the beachfront location allows for an abundance of water recreation. According to Travel + Leisure, “its aqua-shuttered estate house and sugary stretch of white sand — famously peppered with a grove of listing palms — are straight-up cinematic, and its collection of luxury cottages make for an Old Florida idyll.” >> Book this hotel for less

Isla Bella Beach Resort (1 Knights Key Blvd. MM 47, 305-481-9451) Marathon

At the threshold of the Seven Mile Bridge, which connects the Middle Keys to the Lower Keys, you’ll find this tranquil and lush retreat. Besides one mile of oceanfront access, Isla Bella Beach Resort has five pools and a marina with water sport. The luxury resort is a 2022 Condé Nast Traveler Readers’ Choice Award nominee and the magazine calls it “elegant and upscale without any trace of pretense — it is one of the Keys’ best resorts.”     >> Book this hotel for less

Hawks Cay Resort (61 Hawks Cay Blvd., 866-347-2675) Duck Key

Midway between Miami and Key West, Hawks Cay Resort is located on the secluded island of Duck Key. Families will love the dolphin encounters, paddling and snorkeling — all customized to age and ability. One Google review praises Hawks Cay for “beautiful and significant family memories [that] were created in this picturesque place.” Plus, USA Today named it the #1 Best Family Resort in 2020.     >> Book this hotel for less